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Laurent Giovangrandi
Staff, Research and Development Engineer
EDUCATION:
- Engineering
degree in micro-engineering (mechatronics), Swiss Federal Institute of
Technology (EPFL), Lausanne, Switzerland, 1995
- Ph.D.
degree in applied sciences, Swiss Federal Institute of Technology (EPFL),
Lausanne, Switzerland, 1999
Doctoral thesis title: Biopatterning of neural cells on
microelectrode arrays
WORK EXPERIENCE:
- 2004
to date - Research and Development Engineer, National Center for Space
Biological Technologies & Transducers Lab, Stanford University,
Stanford, CA, USA
- 2000
to 2004 - Post-doctoral fellow at the Transducers Lab, Stanford University, Stanford, CA, USA
- 1999
to 2000 - Research associate at the Institute of Physical Chemistry
(ICP), Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland
RESEARCH
INTERESTS:
Biological microsystems and their applications to fundamental research,
biosensing and drug screening. Aspects related to the interfacing of
biological components with artificial microsystems, such as cell-surface
interactions and cell culture support in vitro. Feature extraction and
analysis of signals from biological sources such as cell-based biosensors and
physiological monitoring systems. Current projects include the development of
cell-based assays and technologies for fundamental research and drug
screening, and the development of analysis and visualization tools for
physiological data acquired by wearable monitors.
PUBLICATIONS:
- O.T. Inan, L. Giovangrandi, and G.T.A. Kovacs, Robust
neural-network based classification of premature ventricular
contractions using wavelet transform and timing interval features,
IEEE Transactions in Biomedical Engineering, accepted.
- L. Giovangrandi, K.H. Gilchrist, R.H. Whittington, and
G.T.A. Kovacs, Low-cost microelectrode array with integrated heater
for extracellular recording of cardiomyocyte cultures using commercial
flexible printed circuit technology, Sensors and Actuators B,
113(1), 545-554, 2006.
- R.H. Whittington, L. Giovangrandi, and
G.T.A. Kovacs, A closed-loop electrical stimulation system for
cardiac cell cultures, IEEE Transaction in Biomedical Engineering,
53(7), 1261-1270, 2005.
- K.H. Gilchrist, L. Giovangrandi, R.H.
Whittington, and G.T.A. Kovacs, Sensitivity of cell-based biosensors
to environmental variables, Biosensors and Bioelectronics, 20(7), 1397-1406,
2005.
- K. Montgomery, C. Mundt, G. Thonier, A. Tellier, U.
Udoh, V. Barker, R. Ricks, L. Giovangrandi, P. Davies, Y. Cagle, J. Swain,
J. Hines, and G.T.A Kovacs, Lifeguard - A personal physiological
monitor for extreme environments, in 26th Annual International
Conference of the IEEE Engineering in Medicine and Biology Society.
2004: San Francisco, CA, United States. 2192-2195.
- M. Mayer, S. Terrettaz, L. Giovangrandi, T.
Stora, and H. Vogel, Functional analysis of ion channels: Planar
patch clamp and impedance spectroscopy of tethered lipid membranes,
in Biosensors, vol. 268, Practical Approach Series, J. Cooper, Ed., 2nd
ed. Oxford, UK: Oxford University Press, 2004.
- R.H.
Whittington, K.H. Gilchrist, L. Giovangrandi, G.T.A. Kovacs, A
multi-parameter, feedback-based electrical stimulation system for
cardiomyocyte cultures, in Proc. 12th International Conference on
Solid-State Sensors and Actuators (Transducers'03), Boston, MA, USA,
June 8-12, 2003, 983-6.
- N.J. Mourlas, K.H. Gilchrist, L. Giovangrandi, N.I.
Maluf, and G.T.A. Kovacs, An in-line osmometer for application to a
cell-based biosensor system, Sensors and Actuators B, March, 83
(2002), no.1-3, 41-47.
- K.H. Gilchrist, L. Giovangrandi, and G.T.A. Kovacs, Analysis
of microelectrode-recorded signals from a cardiac cell line as a tool
for pharmaceutical screening, in Proceedings of the 11th
International Conference on Solid-State Sensors and Actuators, June 10 -
14, 2001, Munich, Germany, p.390-393.
- K.H. Gilchrist, V.N. Barker, L.E. Fletcher, B.D.
DeBusschere, P. Ghanouni, L. Giovangrandi, and G.T.A. Kovacs, General
purpose, field-portable cell-based biosensor platform. Biosensors
and Bioelectronics. 16(7-8), 557-564, 2001.
- L. Giovangrandi, C. Schmidt, M. Mayer and H. Vogel, An
emerging technology towards functional screening of membrane channels
and single cell recording, in Proc. 2nd MEA meeting:
Substrate-integrated Microelectrode Arrays: hard-, soft- and wetware,
Reutlingen, Germany, 2000.
- L. Giovangrandi, S.A. Makohliso, P. Aebischer, and M. Ilegems, Biopatterning
of neural cell adhesion on microelectrode array, in Proc. International
Meeting on Substrate-Integrated Microelectrode Arrays: Technology and
Application, Reutlingen, Germany, 1998.
- S.A. Makohliso, L. Giovangrandi, D. Léonard,
H.-J. Mathieu, M. Ilegems, and P. Aebischer, Application of Teflon-AF
thin films for biopatterning of neural cell adhesion, Biosensors and
Bioelectronics, 13(11), 1227-1235, 1998.
- S.A. Makohliso, D. Léonard, L. Giovangrandi,
H.-J. Mathieu, M. Ilegems, and P. Aebischer, Surface characterization
of a biochip prototype for cell-based biosensor applications,
Langmuir, 18(8), 2940-2946, 1998.
- D. Léonard, S.A. Makohliso, L. Giovangrandi, H.-J.
Mathieu, M. Ilegems, P. Aebischer, The role of TOF-SIMS towards the
development of a cell-based biosensor, in Proc. 11th Int. Conf. on
Secondary Ion Mass Spectrometry (SIMS XI), Orlando, USA, p.158, 1997.
- S.A. Makohliso, P. Aebischer, L. Giovangrandi, H.J.
Bühlmann, and M. Dutoit, A biomimetic materials approach towards the
development of a neural cell-based biosensor, in Proc. 18th Annual
International Conference of the IEEE Engineering in Medicine and Biology
Society, Amsterdam, Netherlands, 1996, 81-2.
- S.A. Makohliso, L. Giovangrandi, H.J.
Bühlmann, M. Dutoit, and P. Aebischer, Towards a neural-based biochip
sensor, in Proc. Society for Neuroscience 25th Annual Meeting, San
Diego, CA, USA, 1995, p.63.
AWARDS
AND HONORS:
- Ville de Lausanne Award (1994), Innovative research
task of high level in the exact, natural or biomedical sciences.
- Omega Prize (1994), Best diploma thesis
CONTACT INFORMATION:
Stanford University
Department of Electrical Engineering
Center for Integrated Systems
CIS 218X
Stanford, CA 94305-4075
Office Phone: 650-723-5646
Email: giovan stanford.edu
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